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Approved Studies

Protocol Study Status Title
Principal Investigator
CTOT-01 Closed Noninvasive Monitoring to Predict Outcome in de novo Kidney Transplant Recipients Peter Heeger, MD
CTOT-02/CCTPT-02 Closed B-Cell Depletion by Anti-CD20 in Renal Allograft Recipients who Develop de novo Anti HLA Alloantibodies Mohamed Sayegh, MD and Anil Chandraker, MD
CTOT-03 Closed Correlation of Donor Proinflammatory mRNA Profiles with Early Outcomes of Thoracic and Abdominal Transplantation Abraham Shaked, MD
CTOT-04 Closed Noninvasive Diagnosis of Renal Allograft Rejection by Urinary Cell mRNA Profiling Abraham Shaked, MD
CTOT-05 Closed Observational Study of Alloimmunity in Cardiac Transplant Recipients Peter Heeger, MD; Mohamed Sayegh, MD; and Anil Chandraker, MD
CTOT-06 Closed A Mechanistic Substudy of the Bristol-Myers Squibb Sponsored Trial "Belatacept Conversion Trial in Renal Transplantation Mohamed Sayegh, MD
CTOT-07 Closed Development of Genomic Signatures for the Prediction, Diagnosis and Prognostication of Liver Allograft Rejection and recurrent Hepatitis C Disease Abraham Shaked, MD, PhD
CTOT-08 Closed Discovery and Validation of Proteogenomic Biomarker Panels in a Prospective Serial Blood and Urine Monitoring Study of Kidney Transplant Recipients - Transplant Proteogenomics Michael Abecassis, MD, MBA
CTOT-09 Closed Immune Monitoring and CNI Withdrawal in Low Risk Recipients of Kidney Transplantation Peter S. Heeger, MD
CTOT-10 Closed Optimization of Belatacept Usage As A Means of Avoiding CNI and steroids in Renal Transplantation Christian P. Larsen, MD and Kenneth Newell, MD, PhD
CTOT-11 Closed Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan®) Therapy in Cardiac Transplantation Mohamed Sayegh, MD
ITN524ST-CTOT-12 Closed Associating Renal Transplantation with the ITN Signature of Tolerance (ARTIST) Kenneth Newell, MD, PhD; Laurence Turka, MD; Anil Chandraker, MD
CTOT-13 Closed A Prospective, Randomized, Multicenter, Two-Parallel Arm Study Evaluating the Overall Efficacy and Safety of Desensitization Therapy on Selected Patients Awaiting Heart Transplantation Peter S. Heeger, MD
CTOT-14 Closed Discovery and Validation of Proteogenomic Biomarker Panels in a Prospective Serial Blood and Urine Monitoring Study of Liver Transplant Recipients - Transplant Proteogenomics Michael Abecassis, MD, MBA
CTOT-15 Closed Optimaztion of NULOJIX® (Belatacept) Usage as a Means of Minimizing CNI Exposure in Simultaneous Pancreas and Kidney Transplantation Kenneth A. Newell, MD, PhD
CTOT-16 Closed Optimaztion of NULOJIX® (Belatacept) Usage as a Means of Avoiding CNI and Steroids in Renal Transplantation Kenneth A. Newell, MD, PhD
CTOT-17 Closed A Retrospective Multicenter Study to Determine 5-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-01 Study Peter S Heeger, MD
CTOT-18 Closed A Retrospective Multicenter Study to Determine 4-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-05 Study Peter S Heeger, MD
CTOT-19 Closed Randomized Controlled Trial of Remicade Induction Therapy for Deceased Donor Kidney Transplant Recipients Peter S Heeger, MD
CTOT-20 Closed A Prospective Multicenter Observational Cohort Study to Define the Risks Factors and Mechanisms of Chronic Lung Allograft Dysfunction (CLAD) Phenotypes Scott M. Palmer, MD, MHS
CTOT-21 Active, Not Recruiting Treg Adoptive Therapy in Subclinical Inflammation in Kidney Transplantation Flavio Vincenti, MD
CTOT-22 Closed Prospective Multicenter Cytomegalovirus (CMV) Specific Immune Monitoring to Predict Patient Risk after Lung Transplantation Scott M. Palmer, MD, MHS
CTOT-23 Closed A Retrospective, Multicenter, Study to Determine Up to 5 Year Clinical Outcomes in Subjects Previously Randomized in CTOT-11 Study Peter S Heeger, MD, Anil Chandraker, MD
CTOT-24 Active, Not Recruiting Regulatory T Cell Modulation in Kidney Transplantation With Biologic Blockade of Dual Effector Pathways, CD28 and IL-6 Flavio Vincenti, MD



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